Tumor pathogenesis of human neurotropic JC virus in the CNS

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Tumor pathogenesis of human neurotropic JC virus in the CNS.

In the last several years, studies have reported the detection of sequences similar to the polyomavirus, Simian Virus 40 (SV40) in human tumors including choroid plexus papillomas and ependymomas. Taken together with well-established evidence that SV40, as well as the human polyomaviruses JC virus (JCV) and BK virus (BKV), are oncogenic in several animal models, new interest has resurfaced rega...

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Persistence and pathogenesis of the neurotropic polyomavirus JC.

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Human Neurotropic JC Virus and Its Association with Brain Tumors

JC virus (JCV) is a human polyomavirus known as the causative agent of the fatal demyelinating disease, Progressive Multifocal Leukoencephalopathy (PML). Further, in experimental animals this virus causes a broad range of tumors of central nervous system origin. Recent studies have suggested the association of JCV with several human tumors most notably malignant brain tumors of childhood, medul...

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ژورنال

عنوان ژورنال: Journal of Neurovirology

سال: 1998

ISSN: 1355-0284,1538-2443

DOI: 10.3109/13550289809114517